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Abstract The spectrum of diseases causing neonatal cholestasis preasents intriiguing problems for future investigation. There are many causes, and the eventual outcome of the specificentity has unique individual features for example; extrahepattic biliary atresia may be the result of the sporadic occurrence of avirus- induced, progressive obliteration of the extrahepatic bile ducts with some degree of intrahepatic bile duct injury. The same sequence of viral ifection with persisting injury may account for sporadic ~ses,of neonatal hepatitis, as suggested by the Landin8 hYPO the landing hypothesis. (1974). Conversely the familial forms of cholestasis, either neonatal hepatitis or instances of intrahepatic cholestasis, are most likely genetic diseases that presents specific defects in the hepatic excretory process or in the bile eecreto’ry apparatus (Danks et at:1977). |