الفهرس 
AIM OF THE WORKOnly 14 pages are availabe for public view
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Abstract
The present work was designed to study the histological and histochemical changes after gamma irradiation of the liver and cochlea of guinea pigs and taste buds of rabbits. The animals were divided into four groups; control group J which were not anaesthetized and non- irradiated; anaesthetized and 11011- irradiated group which were anaesthetized with ketamine and thiopental ; anaesthetized and irradiated group which were managed as before then irradiated with 600 rads; non- anaesthetized and irradiated group whose livers were irradiated with two different doses (600 and 800 rads) in order to detect the effect of dose variation. After weighing the control and irradiated animals, the selected organs were taken at time intervals of 1, 3, 5, 7, 10, 15 and 25 days following irradiation. The livers were weighed and specimens were subjected to histological (haematoxylin & eosin and silver) and histochemical {acid and alkaline phosphatases, succinic dehydrogenase, cholinesterase, Best’s carmine, PAS and Sudan black) staining techniques. The mean values of the percentage of the liver / body weights were statistically analyzed. Comparing the effects of a single theraputic doses of ketamine and thiopentaI;no differences were obtainad in non- irradiated and irradiated groups in the different studied organs. 1- Irradiated liver The peak of the percentage of the mean value of the liver/ body weights was highest in irradiated livers under anaesthesia while after irradiation without anaesthesia, it was higher for the (800) compared to the (600) rads dose of irradiation. On the first day after liver irradiation under anaesthesia, there were signs of concomitant nuclear and cytoplasmic degenerative changes. The nuclei appeared pyknotic, while the cytoplasm showed a lower succinic dehydrogenase activity - reflecting mitochondrial degeneration - and was prominently vacuolated. With PAS, carmine and Sudan black staining,