الفهرس | Only 14 pages are availabe for public view |
Abstract Psoriasis is a polygenic skin disease characterized by epidermal hyperplasia and excessive keratinization that affects 1-3% of the general population. The disease can progress to be fulminant and life endangering (Farber and VanScott, 1979). Although many factors such as trauma, infection, climate, light and drugs are known to be a potentially provocating factors, yet the pathogenesis of Psoriasis remains largely unknown and the presently available treatments are unsatisfactory (Wallach and Cottenot 1982). One of the recent therapeutic modalities in psoriasis therapy is dialysis. Chugh et al (1978) reported clearing of resistant psoriasis with hemodialysis in three non-uremic patients. Also improvement of psoriasis after peritoneal dialysis had been reported (Twardowski et al 1978; Halevy et al 1979). On the other hand, Nissenson et al (1979), in a controlled trial comparing the effect of sham and real hemodialysis on psoritatics, showed that dialysis has no effect. Moreover, the appearance ofpsoriasis during dialysis was also observed (Breathnach et al, 1979; Friedman and Delano, 1979). These confilicting results had stimulated us to study the effect of dialysis (both hemodialysis and peritoneal dialysis) on psoriasis, in a comparative study with one of the conventional lines of therapy namely a modification of Goeckerman’s technique. |