الفهرس 
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Abstract
This study was designated to evaluate the effect of preoperative hydration on C02-pneumoperitoneum induced acid-base
changes during laparoscopic cholecystectomy.
The study included 40 adult patients who were randomly allocated into two equal groups (20 patients each). The first group received preoperative hydration with 15 ml/kg fluid load of 5% glucose & Ringer’s solution (2 : 1). The second received the routine fluid intake ((6ml/kg of similar solutions) during the operation. Oral premedication with (5-10 mg) midazepam was given one hour before the induction of anaesthesia, which was achieved by thiopentone sodium (5 mg/kg) and fentanyl (5 I-lg/kg). Suxamethonium (1 mg/kg) was used to facilitate tracheal intubation.
Anaesthesia was maintained by halothane (0.5-10/0) in oxygen.
The muscle relaxant was d-tubocurarine (0.5 mg/kg). Ventilation was controlled mechanically (VT =1 Oml/kg & R/R= 12/min).
Intraperiotoneal C02 insufflation was performed and intraperitoneal gas pressure was maintained at 15 cmH20 by regulated C02 inflow. ECG, HR, BP, Sa02 & EtC02 were monitored throughout the whole procedure as well as in the post operative period.