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العنوان
Synthesis of certain 1­-Adamanty derivatives of expected pharmacological activity /
المؤلف
Hassan, Ghada Sameh Hafez.
هيئة الاعداد
باحث / Ghada Sameh Hafez Hassan
مشرف / Ali Abdel-Rahman EI-Emam
مشرف / Laila M. Gad
مشرف / Alaa ElDin M. Barghash
مشرف / Hassan Hussan Farag
الموضوع
Pharmacological activity. Organic compounds. Chemicals.
تاريخ النشر
2002.
عدد الصفحات
98 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الصيدلة ، علم السموم والصيدلانيات
الناشر
تاريخ الإجازة
1/1/2002
مكان الإجازة
جامعة المنصورة - كلية الصيدلة - Medicinal Chemistry
الفهرس
Only 14 pages are availabe for public view

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Abstract

Several adamantane derivatives have long been known for diverse biological properties, mainly as antiviral, antibacterial, antifungal and anti­inflammatory agents. In addition, several tetrazoles, thiazolidinones and 1,3,4­oxadiazoles were reported to possess various biological activities. On these bases new series of 1­adamantyl derivatives have been synthesized as potential antiviral and/or antimicrobial agents. In order to obtain the target compounds, the following routes were adopted: 1.The reaction of 1­bromoadamantane I with formamide to yield N­(1­adamantyl)formamide II, which was subsequently dehydrated to 1­adamantylisocyanide III. Treatment of III with hydrazoic acid yielded 1­(1­adamantyl)tetrazole IV. 2.Treatment of IV with piperidine or morpholine and aqueous formaldehyde solution at ambient temperature yielded the corresponding 1­(1­adamantyl)­5­piperidino or morpholino­methyltetrazoles Va,b.