الفهرس 
Chronic Inflammation, Malnutrition and Anemia in End-Stage Renal Disease and DialysisOnly 14 pages are availabe for public view
 |  | from | 136 |  |  |
| | | from | 136 | | |
Abstract
Background: The levels of serum inflammatory biomarkers such as C-reactive protein (CRP) and interleukin-6 (IL6) have been discovered to be significantly elevated in around 30 to 50 percent of patients of chronic kidney disease (CKD).
Aim of the Work: To study the effect of lactoferrin therapy on serum IL6 and anemia as markers of Malnutrition and inflammation in prevalent hemodialysis patients.
Patients and Methods: interventional case control study, conducted at Ain shams university hospital hemodialysis unit on 70 prevalent hemodialysis patients divided into 2 groups: (group A): 35 patients with functional iron deficiency anemia, received lactoferrin together with the recommended dose of ESA therapy for 3 months, (group B): 35 patients with functional iron deficiency anemia, received only their recommended dose of ESA therapy for 3 months.
Results: Both groups were age and sex-matched. In lactoferrin treated group,there was statistically significant decrease in inflamatory markers, but there was no statistically difference in hemoglobin after 3 months post therapy in both groups.
Conclusion: Lactoferrin has beneficial anti-inflammatory effect, with no additive effect in management of iron-deficiency anemia and inflammation in prevalent hemodialysis patients.