الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Sesame seeds have been valued for centuries for their high oil content in addition to their other nutritional benefits. They are an important part of the human diet for the reason that they include a variety of nutrients, including protein, essential oils, unsaturated and saturated fatty acids, vitamins, antioxidants, and dietary fibers. Sesame is an essential annual seed crop all over the tropics and subtropics. The majority of the world’s sesame crop has been grown in developing nations, especially in China, India, Myanmar, Sudan, Nigeria, and Uganda.
Peanuts are an outstanding source of fiber, folate, niacin, vitamin E, magnesium, and phosphorus besides being high in protein and fat. Raw peanuts can be processed into peanut butter, oils, and many more items in addition to being used in recipes. In Asian countries, particularly China, peanut oil is considered an essential food source.
The usage of pesticides for agricultural reasons has risen, harming human health and causing damage to the environment. Many consumptions of pesticide rules are being worked out, especially regarding residual levels in processed foods like sesame and peanuts. The Food and Agriculture Organization (FAO), the World Health Organization (WHO), and the European Union are among the organizations that created maximum residue limits (MRLs) for several pesticides in food.
It is challenging to investigate these fatty matrices, particularly sesame and peanuts, because of their high fat content and complex matrices that limit the analysis’s determination stage. This leads to the development of a new method to help the solvent penetrate the tissue to extract the analytes. The extraction was carried out by using ultra-turrax blending by grinding the sample with extraction solvent.
The validation of the developed method by testing the following parameters:
1. Limits of Quantification (LOQ) which was in the range of 0.01-0.05 mg/kg for all target pesticides.
2. Recovery and Accuracy which were in the acceptable range of 70-120%.
3. Method Linearity which gave acceptable regression coefficients r2 > 0.99 for all target pesticides.
4. Method Repeatability on different concentration levels (0.01, 0.05, 0.1 mg/kg) which gave acceptable recovery in the range of 70-120%.
5. Studying matrix effect on pesticide residues determination.
The QuEChERS technique has been applied to different matrices and for the extraction of a broad range of compounds in recent years. It has been verified that the novel extraction technique, which was a modification of the popular ”Quick Easy Cheap Effective Rugged and Safe (QuEChERS)” extraction method, could identify 377 pesticide residues in sesame and 388 pesticide residues in peanuts. This technique was investigated using gas chromatography triple quadrupole mass spectrometry (GC–MS/MS) and high-performance liquid chromatography triple quadrupole mass spectrometry (LC–MS/MS). It was validated using a variety of validation parameters that include a limit of quantitation (LOQ), linearity, matrix effect, precision, and trueness, by SANTE guideline 11312/2021.