الفهرس 
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Abstract
In acute decompensated Heart Failure (ADHF), many of the signs, symptoms and disease progression are explained by congestion. Carbohydrate antigen (CA) 125, a tumor marker, is shown to be a surrogate for congestion and inflammation.
We investigated CA 125 compared to NT-proBNP in 70 participants equally divided into 35 cases with ADHF and 35 age-matched healthy controls then follow up after 3 months of treatment. Relationship of CA 125 to complications (Death or rehospitalization for HF) was assessed together with its cost effectiveness compared to NT-ProBNP
Our results revealed that CA 125 was significantly higher in ADHF cases than in controls . Also CA 125 was lower in the patients who eventually survived compared to those who eventually
Among survived patients , we noticed that level of CA 125 was higher in those with heart failure related readmissions within 3 months compared to those who weren’t readmitted .
Patients with complications (death or HF readmission) showed a higher level of CA 125 compared to uncomplicated patients.
There was strong positive significant correlation coefficient between CA125 and NT-proBNP in diagnosis of ADHF (r = 0.81) with significant p value <0.05
Also, moderate positive correlation coefficient between CA125 and NT-proBNP among complicated cases was found (r=0.56) with significant p value <0.05
Finally, we found that Incremental Cost effectiveness ratio (ICER) of NT-proBNP was higher than CA 125, CA 125 gives same diagnostic value as NT-proBNP with less cost so CA 125 is cost effective test.