الفهرس 
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Abstract
CD64 [Fc gamma receptor 1 (FcγRI)] & HLA-DR is an MHC class
II molecule tested as biomarkers used in predicting severe bacterial
infection. The study was designed to assess their level in ICU patients
with liver cirrhosis as a possible biomarker of inflammation.
A case-control study was conducted, 70 patients with liver cirrhosis
(35 with sepsis & 35 without sepsis), 30 healthy individuals as a control
group. Laboratory and imaging studies were evaluated. The levels of
CD64, HLA-DR expressions in peripheral blood and Sepsis Index were
measured for all patients by flowcytometry using fluorescein
isothiocyanate (FITC)-conjugated anti-CD64 monoclonal antibody and
(FITC) Anti-Human HLA-DR Antibody.
The levels of CD64, HLA-DR and SI in peripheral blood have
higher statistically significant in sepsis compared to control group with P
Value (PMN CD64% 0.001, PMN CD64 MFI 0.001, PMN HLA-DR%
0.001, Monocyte CD64% 0.003, Monocyte CD64 MFI 0.001, Monocyte
HLA-DR MFI 0.002 and SI 0.001). Although, the levels of CD64
expressions in peripheral blood, HLA-DR and Sepsis index have no
statistically significance in sepsis in liver cirrhotic patients and patients
without sepsis except (highly statistically significance Monocyte CD64%
0.003 & statistically significance Monocyte CD64 MFI 0.030). Also, in
cirrhotic patients with sepsis ALBI score and S.Lactate level showed
highly statistically significance wit P Value (0.017 and 0.001).
The levels of Monocyte CD64% and Monocyte CD64 MFI
expressions in peripheral blood are considered good biomarkers of sepsis in liver cirrhosis. Also, ALBI score and S.Lactate level are considered
good indicator for sepsis in patients with liver cirrhosis.