الفهرس 
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Abstract
Background: Neonatal encephalopathy is a heterogeneous condition that can be due to any disorder that disrupts the central nervous system in the first days of life. The B-type natriuretic peptides are predominantly synthesized and released constitutively from ventricular cardiac myocytes.
Aim and objectives: To evaluate the diagnostic value of N-terminal pro-brain natriuretic peptide biomarker in the assessment of myocardial ischemic injury in neonates with hypoxic ischemic encephalopathy. The main objective was to assess level of NT-proBNP biomarker in assessment of myocardial ischemic injury in neonates with hypoxic ischemic encephalopathy.
Methods: A case control study was carried out in NICU of Suez Canal University Hospital. The study was conducted over newborns (aged ≤ 28 days) who diagnosed with hypoxic-ischemic encephalopathy in NICU of Suez Canal University Hospital and fulfilling the inclusion and exclusion criteria.
Results: The mean age of the HIE group was 16.2± 7.6 days. Two-thirds of the participants were males. Only three patients in HIE and one patient had premature rupture of membrane. Eleven patients showed myocardial ischemic injury and twenty percent had severe HIE. NT-proBNP showed significantly higher levels among the HIE compared to control group. Severe HIE had the highest level of NT-proBNP followed by moderate then mild HIE. The presence of Myocardial injury was associated with higher levels of NT-proBNP than HIE without myocardial injury. At cut off value ≥ 252, the area under the curve was 79.1% the NT-proBNP had a diagnostic value of myocardial ischemic injury with sensitivity of 90.9%, specificity of 97.1%, NT-proBNP is a predictor for myocardial injury among patients with HIE.
Conclusion: NT-proBNP level increase in neonates with HIE than controls and increases with severity of HIE. NT-proBNP level increase in neonates with myocardial ischemic injury than those without myocardial ischemic injury.
Keywords: NT-proBNP, hypoxic-ischemic encephalopathy, HIE, BNP.