الفهرس 
Wound HealingOnly 14 pages are availabe for public view
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Abstract
This study comprehensively evaluated patients with critical limb
ischemia (CLI) undergoing revascularization interventions, focusing on
demographics, comorbidities, laboratory findings, wound characteristics,
clinical outcomes, survival analysis, and predictors of wound healing.
Demographics and Comorbidities: The study included 114 patients
with CLI, with a median age of 60 years, a majority being male (64.9%), and
a notable percentage being smokers (45.6%). Common comorbidities
included diabetes (77.2%), hypertension (45.6%), and chronic kidney
disease (42.1%). Ambulatory status varied, with 78.1% being ambulant and
21.9% bedridden.
Laboratory Investigations: Patients exhibited elevated total leucocytic
count (TLC) and positive C-reactive protein (CRP) levels, indicative of an
inflammatory response. Median hemoglobin level was 11.5 g/dL, and
median serum albumin level was 2.9 g/dL.
Tissue Loss and Wound characteristics: Tissue loss primarily
presented as gangrene (51.8%) and ulcers (42.1%), with a smaller percentage
experiencing minor amputations (6.1%). Most patients had single wounds
(89.5%), mainly located in the toes (58.8%) and heels (29.8%). Wound
infections were prevalent in 50.9% of patients.
Clinical Outcomes: Endovascular intervention was more common
(85.96%) than open surgery (14.04%). Successful wound healing occurred
in 43% of patients, with a median healing duration of 112 days. Major
amputation and death rates were 5.2% and 8.8%, respectively.
Survival Analysis: Kaplan-Meier analysis showed gradual wound
healing over 180 days, with complete healing observed in 43% of patients.
Ambulant patients had higher healing rates compared to bedridden patients,
and heel site wounds exhibited slower healing rates.
Predictors of Wound Healing: Multivariate logistic regression
identified age < 60 years and endovascular intervention as predictors of
higher odds of wound healing. Conversely, being bedridden and having
wound infection were associated with lower odds of healing.
The study highlights the multifaceted nature of CLI and emphasizes
the importance of tailored interventions and infection control in optimizing
clinical outcomes. These findings contribute to the understanding of factors
influencing wound healing and inform clinical decision-making in the
management of CLI.