الفهرس 
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Abstract
Colorectal carcinoma (CRC) is a major health problem. It is the
third most common malignancy worldwide and the fourth most common
cause of cancer-related death. In Egypt, it represents about one third of
the whole gastrointestinal tumors, ranking the third in male and the fourth
in female.
The interactive relationship between tumor cells and immune
microenvironment has been involved in colorectal carcinogenesis. The
antigens produced by emerging tumor cells stimulate immune response in
different immune cells especially T lymphocytes (TILs). On the other
hand, a different type of T-cells, regulatory T- cells (Tregs) suppress
immunity protecting tumor cells from immune attack.