الفهرس | Only 14 pages are availabe for public view |
Abstract This study delves comprehensively into the demographic, clinical, and laboratory aspects of post-kidney transplanted recipients, offering a nuanced exploration of their characteristics and postoperative outcomes. The diverse sample of 41 recipients, with a mean age of 29.63 years, reflects the complexity of this patient population, encompassing various chronic kidney disease etiologies and comorbidities, most notably hypertension. The study’s findings provide a valuable snapshot of the preoperative landscape, emphasizing the predominance of non-smokers and revealing intriguing autoimmune markers, with negative complement C3 and C4 levels and low prevalence of positive autoantibodies. Operative details underscore the efficiency of the transplantation process, with a short mean total ischemia time, a high percentage of cases not requiring intra-operative blood transfusion, and an encouraging incidence of immediate diuresis. The predominant use of tacrolimus as an immunosuppressive agent aligns with established protocols, yet the variations in induction types add complexity to the immunomodulatory approaches employed. The postoperative phase is meticulously explored, revealing a dynamic pattern of electrolyte and acid-base disturbances. Within the first month, a substantial proportion of cases experienced hyponatremia, hypomagnesemia, and hypophosphatemia, alongside a notable prevalence of metabolic acidosis. Beyond six months, hyperkalemia and hypercalcemia become more prevalent, emphasizing the evolving nature of post-transplant metabolic challenges. Significantly higher levels of various markers at six months compared to the first month suggest an overall improvement in metabolic and electrolyte homeostasis over time, providing valuable insights for postoperative management. The association between blood tacrolimus levels and bicarbonate abnormalities adds a layer of complexity to our understanding of immunosuppressive therapy and its impact on metabolic parameters. However, the study’s limitations, including a small sample size and singlecenter design, underscore the need for caution in generalizing the findings. The recommendations for future research, advocating for multi-center studies, extended follow-up periods, and a focus on comparative analyses of immunosuppressive regimens, offer a roadmap for advancing our understanding of postoperative complications in kidney transplant recipients. In conclusion, this study contributes valuable data to the evolving landscape of kidney transplantation, providing a foundation for future investigations aimed at optimizing care strategies and improving outcomes for this vulnerable patient population. |