الفهرس | Only 14 pages are availabe for public view |
Abstract Acute kidney injury (AKI) is a complex disorder (AKI) means the sudden loss of kidney function generally occurring over the course of hours to days and resulting in the retention of metabolic waste products and dysregulation of fluid, electrolyte, and acid-based homeostasis. Acute kidney injury (AKI) is common in critically ill premature neonates. Serum creatinine in the first few days of the neonate’s life reflects the mother’s and not the infant’s renal function. Novel urinary biomarkers can diagnose acute kidney injury within hours of an insult have been discovered. Plasma creatinine has many limitations as diagnosis is often delayed and imprecise in the setting of critical illness. Biomarkers of AKI are heterogeneous molecules. Some appear to be produced directly within the kidney as a result of tubular injury or stress urinary neutrophil gelatinaseassociated lipocalin (NGAL) others may appear in the urine due to failure of proximal tubular uptake such as urinary cystatin c, while others again may simply be more precise markers of alteration in glomerular filtration rate (serum cystatin c – CysC), and interleukin 18. Glutathione S-transferase (GST) isoenzymes catalyze the conjugation of reduced glutathione and exhibit other GST-dependent catalytic activities including the reduction of organic hydroperoxide and isomerization of various unsaturated compounds. Glutathione S-transferase is in proximal tubules and Bowman’s capsule before the 35th week of gestation, and only after this gestational week does it get found in distal tubules. That is why, the releasing of Glutathione S-transferase from damaged proximal tubules occurs in prematurely born neonates. The level of serum GST could be an estimated glomerular filtration rate-independent factor involved in kidney damage. So, the aim of this study was to assess the role of serum glutathione Stransferase (GST) for early detection of acute kidney AKI in neonates. To elucidate our aim, this prospective study was carried out on 83 neonates admitted into NICU of Menoufia University hospital to study glutathione S-transferase as a predictor of acute kidney injury during a period time from November 2019 to February 2021. |