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Abstract According to the World Health Organization WHO (2017) liver disease deaths in Egypt had a rank number one in the world because most patients with chronic liver disease do not seek treatment until late in the course of the disease that lead to development of complications and hepatic ence phalohy pat which is one of the most serious complication of liver diseases and responsible for the major cause of admissions and high mortality in cirrhotic patients. It is occur in 70% of patients with cirrhosis that manifests as a wide range of neuropsy chological clinical findings ranging from minimal HE to coma (Ali et al., 2023 & Mahmoud et al., 2021) So educational nursing intervention is critical in minimizing hepatic encephalopathy episodes because early identification of precipitating factors is extremely important in diagnosis and treatment of this fatal condition. The clinical course of hepatic encephalopathy can be interrupted in majority of patients by controlling these precipitating factors. Hence early and accurate diagnosis and proper identification of precipitating factors will help in initiating the appropriate treatment and thereby bringing down the morbidity and mortality (Peng et al., 2021). The purpose of this study was to determine the effect of educational nursing intervention on occurrence of hepatic encephalopathy among patients with liver cirrhosis out at endemic diseases department, outpatient clinic of Menoufia University Hospital and Liver Institute in Shebin El-Kom, Menoufia Governorate, Egypt. Subjects: A consecutive sample of 100 adult patients with liver cirrhosis were assigned randomly and alternatively into two equal groups, 50 patients for each group - Study group (I): patients received the structured educational nursing intervention along with routine hospital care - Control group (II): patients was exposed to routine hospital care only Instruments of the study: Three instruments were used for data collection Instrument I: - Structure interview questionnaire. Instrument II:- Bio - physiological measurement instrument. Instrument III:- West-Haven criteria scale (WHC scale The main findings of the present study were • There was highly significantly improvement in total knowledge level among study group (I) than control group (II) immediately post intervention and after Months There was highly significant reduction in hepatic encephalopathy episodes and less severity grade among study group (I) than control group (II immediately post intervention and after 2 months Conclusion • Educational nursing intervention had significant effect on improving the total knowledge level among study group (group I) than control group (group Educational nursing intervention had a positive impact on reducing hepatic encephalopathy episodes and its severity grade among study group (group I) than control group (group mRecom mendations Supervised health teaching to improve patient’s knowledge and awareness about liver cirrhosis, hepatic encephalopathy, its prevention and early detection should be implemented • Establishing a web site, including all pertained information of hepatic encephalopathy and all aspect of health education such as different education materials, medias and audio-visual aids |