الفهرس 
Introduction & Aim of the workOnly 14 pages are availabe for public view
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Abstract
This study aims to clarify the protective role of pomegranate peel methanol extract (PPME) in repressing acute-kidney injury (AKI) caused by cisplatin (CP). It also compares between PPME protective effect versus its treatment efficacy on the 5th and 14th days after a daily oral dose of PPME. Cystatin-C (CYS-C) and endothelin-1 (ET-1) were used as markers of AKI in tissue homogenate. kidney inflammation was quantized using tumor necrosis factor-α (TNF-α). Apoptotically damaged renal tissue was evaluated using caspase-3 (Casp-3). Oxidative stress indicators (malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD), and glutathione (GSH)) were rated. Microalbuminuria (MAU), serum creatinine (Cr), and blood urea nitrogen (BUN) were also estimated. Finally, histopathological examination confirmed kidney tissue damage and/or its repair. This study showed that taking PPME was successful in enhancing renal reparative processes by decreasing CYC-C and ET-1 levels plus reducing the levels of TNF-α, Casp-3, NO, MDA, MAU, serum Cr, and BUN. Moreover, the increment in SOD and GSH as well as the regeneration of the outer medulla, reduction in tubular dilation, and decreased necrotic changes in the cortex and medulla verify the capability of PPME to repair CP-induced AKI.PPME has been shown to have beneficial effects of PPME on CP-induced AKI in rats possibly via anti-inflammatory, antioxidant, and apoptosis-resisting mechanisms.