الفهرس 
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Abstract
The thesis aimed to investigate the protective effects of lipopolysaccharide from Rhodobacter- sphaeroides (LPS-RS) against ethanol-induced hepatotoxicity and nephrotoxicity in experimental rats. Ethanol significantly increased the expression of nuclear factor kappa B (NF-κB) and levels of malondialdehyde (MDA), tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) in the liver tissue and decreased the anti-oxidant enzymes. Hepcidin expression was down-regulated in the liver, with increased serum levels of ferritin and iron.
Prior-administration of LPS-RS alleviated the increase in oxidative stress and inflammatory markers, and preserved iron homeostasis markers. In the kidney, administration of ethanol caused significant increase in the expression of NF-κB and the levels of TNF-α and kidney injury markers; whereas LPS-RS + ethanol groups had significantly lower levels of those parameters. In conclusion; this study reports anti- oxidant, anti-inflammatory and iron homeostasis regulatory effects of the toll-like receptor (TLR4) antagonist LPS-RS against ethanol induced toxicity in both the liver and the kidney of experimental rats.
Name: Al-Shimaa Ahmed Ali Sayed
Nationality: Egyptian
Date and location of birth: 9/30/1992 – Cairo – Egypt
Publication: “Anti-Oxidant and Anti-Inflammatory Effects of Lipopolysaccharide from Rhodobacter- Sphaeroids against Ethanol Induced Liver and kidney Toxicity in Experimental Rats”. https://doi.org/10.3390/molecules2624747437
Title of The Thesis: Biochemical Effect of Lipopolysaccharide from Rhodobacter-Sphaeroids on Liver Toxicity in Rats
Degree: master Degree in Pharmaceutical Sciences
Specialty: Biochemistry
Language: English