الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
 |  | from | 125 |  |  |
| | | from | 125 | | |
Abstract
Type 2 diabetes (T2D) is a combination of early insulin resistance and progressive loss of pancreatic β cell function, resulting in insufficient amounts of insulin and subsequent hyperglycaemia. Conglutin Gamma (Cγ), is a glucose-lowering protein that is purified from Lupinus albus seeds. Adipocytokines are hormones secreted by the adipose tissue and their main role is signalling key organs to maintain metabolic homeostasis. This study aimed to identify and compare the role of Cγ and glimepiride in controlling hyperglycemia, insulin secretion, insulin resistance and hyperlipidemia in high-fat diet and low- dose streptozotocin (STZ) induced T2D experimental rats through affecting the expression of various adipocytokines. Groups of male SpargueDawely rats were assigned to normal group, Cγ control group, T2D control group and four T2D groups treated with Cγ (30, 60, and 120 mg/Kg) and Glimepiride (0.1 mg/kg). Cγ administration effectively abrogated hyperglycemia and enhanced insulin secretion and sensitivity. Moreover, administration Cγ ameliorated Chitotriosidase enzyme activity, the expression of leptin, Adiponectin and thier serum concentration, NAMPT and RBP4 expression compared to (STZ+HFD) control rats and effectively downregulated apelin expression. The present data suggests that Cγ has an effective role on controlling hyperglycemia induced by diabetes through amelioration of leptin, adiponectin, liver enzyme levels, lipid profile and metabolic syndrome.
Keywords:Adipocytokines; Conglutin Gamma; Insulin resistance; Diabetes.