الفهرس 
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Abstract
Coronary Artery Disease (CAD) is characterized pathologically by atherosclerosis formation which is the predominant cause of death. The chronic inflammatory response is associated with production of platelets and lymphocytes. Elevated platelet counts accelerate atherosclerosis formation, and destabilization of atherosclerotic plaques. Platelets act as a bridge between local inflammation at the vascular wall and development of atherosclerotic plaques.
Platelet volume indices, such as mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT) and platelets are indicators of platelet activation and are routinely reported as part of an automated full blood count. Platelet function disorder has also been implicated in the pathogenesis of ST-segment–elevation myocardial infarction (STEMI).
These platelet indices are thought to be associated with atherosclerosis and inflammation. PDW is a measure of variation in the size of circulating platelets and is an indicator of platelet activation. Its increase could represent the release of larger reticulated platelets from bone marrow cells.
Anisocytosis of platelets may have higher thrombotic potential. In a recent study, PDW has been linked to the severity of coronary artery disease (CAD) in patients with acute coronary syndrome.
Plateletcrit reflects the number of platelets in a unit blood volume and is a marker of total platelet mass. PCT =) platelet count × MPV / 10,000 (has been found to be correlated with CAD.
The size of the platelets, represented by MPV, is a potentially useful marker of platelet function. The MPV provides a simple, but promising, method to evaluate platelet function and systemic inflammation and it is widely used as a prominent marker for cardiovascular diseases. Several studies have shown a significant association between MPV and coronary artery disease. However, only a few studies have evaluated the association between PCT, PDW and coronary artery disease.
The main aim of this study was to assess the platelet indices in patients with acute ST- elevation Myocardial Infarction (STEMI) Undergoing Percutaneous Intervention and relation to the severity of coronary artery disease and short-term clinical outcomes.
This prospective cross-sectional study was conducted at Emergency reception unit, Critical Care Unit at Internal Medicine Department, Assiut University Heart Hospital, and Assiut University Hospital. The study included 115 adult patients, aged ≥ 18 years and presented with acute ST- elevation Myocardial Infarction (STEMI).