الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
This is a case control study conducted at Tanta University Hospital’s Clinical Pathology and Oncology Departments and aimed to evaluate serum Cyr61’s potential as a biomarker for diagnosis patients with CRC. A total of 90 subjects who were categorized into two groups, as follows: -group I: 45 patients with CRC. -group II: 45 apparently healthy subjects with no family history of CRC. Inclusion criteria All patients newly diagnosed with CRC based on colonscopic biopsy, radiological investigations, and confirmed by histopathological examination were included in this study. Exclusion criteria Patients with CRC who had distant metastasis, therapy, surgical resection, and synchronous malignancy were excluded from this study. Methods All the studied groups were subjected to the following: 1) Full history taking, including age, gender, and present history including abdominal pain, constipation, vomiting, and intestinal obstruction. 2) Clinical examination, including general, abdominal, and chest examination 3) Radiological investigations a) Pelvi -abdominal ultrasonography b) Computerized tomography scan (CT) on chest and abdomen in patients with CRC 4) Colonoscopy and colonic biopsy with histopathological examination for patients with CRC. 5) Laboratory investigations A) Routine investigations 1- Renal function tests. 2- liver function tests. 3- Serum CA 19-9 level. 4- Serum CEA level. B) Spesific laboratory investigations Measurement of serum Cyr61 (CCN1) level using ELISA. Main findings of our study can be summarized as follow; - Regarding site, colon cancer was more common than rectal cancer. - Tumors in ascending colon were more common than tumors in descending, anorectal, and transverce colon. - Moderately differentiated tumors were more common grade in CRC. - Serum creatinine, urea, bilirubin, ALT, and AST were higher in cases with CRC than healthy controls while serum albumin levels and total protein levels were lower. - Serum levels of CEA and CA 19-9 were significantly higher in CRC group than control group. - Serum Cyr61 levels in CRC group were significantly higher than in healthy controls. - Serum Cyr61 levels had a significant positive correlation with serum CEA and CA 19-9 levels in the case group. - Serum Cyr61 and CA19-9 were related to CRC in univariable logistic regression. However, in multivariable analysis, serum Cy61 levels were only independently related to CRC. - The ROC curve analysis of Cyr61 between CRC and control groups revealed that the Cyr61 was a significant predictor to CRC disease at a cutoff 244.7 pg/ml (AUC= of 0.980, sensitivity = 95.56%, and specificity = 93.33%).