الفهرس | Only 14 pages are availabe for public view |
Abstract The relationship between cardiovascular diseases and glucose metabolism has drawn a lot of attention for decades. The central part of this attention was paid towards the relationship between those diseases and Diabetes Mellitus (DM) which is by far the most important systemic metabolic disease we have ever known. Numerous studies that prediabetes, a minimally aberrant glycometabolism, has an independent relationship with cardiovascular disease (CVD) and that it reflects an escalation in the severity and complexity of CAD. Aim of the work : The aim of our study was to assess the correlation between both glycosylated hemoglobin (HbA1c), fasting blood glucose (FBG) and the severity of coronary artery disease in prediabetic patients undergoing elective coronary angiography . Methods : The study was conducted on 92 prediabetic patients who underwent elective PCI in cardiology department in National Institute of Diabetes and Endocrinology and Cardiology Department of Menoufia University Hospitals After informed written consent was obtained, All patients were subjected to the following: Full history taking including: age, other cardiovascular risk factors (smoking, hypertension, dyslipidemia & family history of coronary artery disease). Full clinical examination including : - General and local cardiac examination. - Vital signs including Blood pressure and HR. - Routine laboratory investigations including : - Complete blood count (CBC) - Fasting blood glucose and HbA1c - Serum creatinine . Coronary angiography: All individuals had coronary angiography per standard protocols using the Judkins technique. Standard views for Left and Right coronary arteries. CAD severity was assessed using SYNTAX score according to diagnostic algorithm. Results: The mean haemoglobin was 13.0 ± 1.7, the mean FBS is 117.8 ± 6.1, while the mean HbA1c was 6.1 ± 0.2. The median of the SYNTAX score among the studied patients was 6.5 (0 - 19). Low SYNTAX score was reported among 80.4% of the patients, intermediate score was 9.8%, while high score was reported 9.8% of the studied patients. There is a significant positive correlation between number of vessel diseased and HbA1c, Also, there is a significant positive correlation between HB%, FBS, HbA1c and Syntax score. The median of the score was significantly higher among males, smokers, hypertensive patients, and those with positive family history for CAD. No significant relationship was observed between the score and age. Linear regression for predictive factors of SYNTAX showed the number of VD was considered an independent predictor of severity of CAD. While sex, smoking, hypertension, HB%, FBS, and HbA1c werecofactors. |