الفهرس 
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Abstract
scottish Guideline defined the chronic venous leg ulcer “as an open lesion between the knee and the ankle joint that remains unhealed for at least four weeks and occurs in the
presence of venous disease”.
Venous Leg Ulcers (VLUs) account for 70% of all leg ulcers and estimates 1% of the population with a prevalence that increases with age according Edinburgh study, which was a cross-sectional study of a random sample.
Venous ulcer is one of the complications of chronic venous insufficiency and is considered the most common cause of lower extremity ulceration. Venous ulcers account for approximately 80% of all lower extremity ulcers, with an overall prevalence of 1–2% chronic venous insufficiency has a great impact on patient‟s health related quality of life (HRQOL), and is associated with considerable health care costs. Surgical treatment is relatively invasive. The rate of recurrence of venous ulcer after treatment has been reported to vary from 20% to 80%. Methods such as endovenous laser ablation; radiofrequency ablation and foam sclerotherapy have been increasingly used in these patients.
Our study was conducted on 50 patients with chronic venous leg ulcers that had been presented for at least four weeks ago. To evaluate the clinical efficacy of Duplex-guided
foam sclerotherapy with compression therapy in comparison with compression therapy alone, we divided the patients with randomization into two groups. group A was conservatively managed by four-layer compression bandage and group B was managed by application of duplex guided injection sclerotherapy and four-layer compression bandage.
In our study, there are statistically non-significant differences between the studied groups regarding age, gender, . There is statistically significant difference between the studied groups regarding duration of ulcer in weeks (which was significantly lower among combined compression and injection group). On the other hand, there is non-significant difference between them regarding ulcer side, site, length, width or surface area.
The results of our study showed that there is statistically significant difference between the studied groups regarding outcome as less duration of healing happened with combined group. The largest percentage of patients within both groups had complete healing by the end. There is significant difference between them regarding number of incompetent perforators (significantly higher in combined groups).
In our study, there is statistically non-significant difference between the studied groups regarding surface area of ulcer at first, fourth, and fifth week. There is significant difference between them at second, third and sixth week. On
studying change in ulcer surface area in both groups over time, there is statistically significant decrease in it in combined group versus non-significant change in compression group.
We reported that there is statistically non-significant difference between the studied groups regarding adverse effect of treatment approaches. There is statistically non-significant difference between the studied groups regarding their tolerability to compression. In combined groups, the largest percentage tolerated gel foam infection.
In our study, there is statistically significant positive correlation between duration of ulcer, ulcer surface area and duration to complete healing. On linear regression analysis of factors significantly correlated with duration of complete healing, only ulcer surface area at start of treatment was significantly associated with it (β=1.031, p<0.001). Increased ulcer surface area at start of treatment by 1 cm2 increases duration of healing by about 1 week.