الفهرس 
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Abstract
The present study aimed to investigate the ameliorative effect of L-arginine (L- A) on cognitive hypofunctions induced by monosodium glutamate (MSG). Thirty-six male albino Wistar rats 10 weeks old (180 to 200g) were divided into
4 groups: group I: received distilled water, group II received L-arginine (L-A)
500 mg/kg, group III received 2 mg/kg monosodium glutamate (MSG), group IV
received L-arginine 500 mg/kg and 2 mg/kg monosodium glutamate by oral
gavage for 10 days. Results revealed that MSG cause decline in cognitive
functions as evidenced by NOR and y-maze tests. It has a neurotoxic effect as
evidenced by increasing MDA level and GPx activity, decreasing SOD and CAT
activities, reduced DA level, histopathological alteration in the brain, decreased
S-2A receptors, and increased apoptosis as demonstrated by promoted caspase-3. Treatment with L-A ameliorated the neurophysiological effects of MSG through
improving memory, decreasing MDA level, GPx activity, increasing SOD and
CAT activities, increasing DA level, improving histoarchitecture of the brain, improving S-2A receptors and decreasing apoptosis ameliorating caspase-3
protein in the brain.