الفهرس 
Gross Anatomy of BoneOnly 14 pages are availabe for public view
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Abstract
Bone is the basic unit of the human skeletal system. It is continuously
remodeled through bone resorption by osteoclasts and bone formation by
osteoblasts. An imbalance between bone resorption and formation can result in
bone diseases including osteoporosis.
There are more than 200 million individuals with osteoporosis
worldwide, and the fracture risk of patients with osteoporosis is as high as 40%.
About 30 % of patients with long-term (over 6 months) use of GC acquired
osteoporosis. Glucocorticoid- induced osteoporosis (GIOP) has become the
most common secondary osteoporosis in adults.
Bisphosphonate drugs: such as alendronate, are recommended as the firstline therapy for the prevention and treatment of generalized glucocorticoids
induced osteoporosis as it suppresses osteoclast activity and slow bone loss.
Even though, there is still a controversy concerning the benefits of
bisphosphonates versus their long term reported complications.
Methyl sulfonyl methane (MSM) is an organosulfur molecule naturally
occurring in the human body and many foods. It has antioxidant, antiinflammatory, anti-atherosclerotic, antiapoptotic and antimicrobial activities.
The present study was performed to study the effect of Methyl
Sulphonyl Methane on the osteoporosis that was induced experimentally by
glucocorticoids in adult male albino rat model compared to alendronate sodium.
The current study was conducted on Seventy-two healthy adult male
albino rats with average weight of 180-200 gm. The rats were classified into six
experimental groups:
group I: this group included 12 adult male albino rats and was subdivided into
2 subgroups:
Subgroup (Ia) (Plain control group): it included six rats and was kept
without any treatment all over the experimental periods and they were served as
control group for all experimental groups.
Subgroup (Ib) (Vehicle-control group): it included six rats. Each rat
received 0.2 ml normal saline oral by gavage for 8 weeks.
group II (MSM group): this group included 12 rats. Each rat received 0.2 ml
normal saline oral by gavage for 4 weeks then received Methyl Sulphonyl
Methane (MSM) (400 mg/kg/day dissolved in 1ml normal saline; about 80
mg/rat dissolved in 0.2 ml normal saline) orally by gavage for another 4 weeks.
group III (Alendronate group): this group included 12 rats. Each rat
received Each rat received 0.2 ml normal saline oral by gavage for 4 weeks then
received Alendronate (1 mg/kg/day dissolved in 1 ml normal saline; about 0.2
mg dissolved in 0.2 ml normal saline/ rat) orally by gavage for another 4 weeks
group IV (Glucocorticoid Induced Osteoporosis group): this group
included 12 adult male albino rats. Each rat received received intramuscular
injection of dexamethasone (7 mg/kg, once/week; about 1.4 mg/ rat or about
0.35 ml of dexamethasone ampoule) for 4 weeks to induce osteoporosis then
each rat received 0.2 ml normal saline oral by gavage for another four weeks to
collect specimens at the end of the experimental period (8 weeks).
group V (Glucocorticoids plus MSM treated group): this group included 12
rats. Each rat received intramuscular injection of dexamethasone (7 mg/kg,
once/week) for 4 weeks then each rat received Methyl Sulphonyl Methane (400
mg/kg/day; about 80 mg/rat) dissolved in 0.2 ml normal saline for 4 weeks
orally by gavage for another 4 weeks.