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العنوان
Aberrant expression of CD56 in hematologic malignancies /
المؤلف
Abdel Mawjoud, Asmaa Hassan Mohamed,
هيئة الاعداد
باحث / Asmaa Hassan Mohamed Abdel Mawjoud
مشرف / Dina Ahmed Mohareb
مناقش / Hisham Abdel Rahim Abdel Basit,
مناقش / Asmaa Muhammad Zahran
الموضوع
Clinical Pathology. sears list.
تاريخ النشر
2024.
عدد الصفحات
105 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الطب (متفرقات)
الناشر
تاريخ الإجازة
11/9/2023
مكان الإجازة
جامعة أسيوط - كلية الطب - Clinical Pathology
الفهرس
Only 14 pages are availabe for public view

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Abstract

This study was performed on 55 patients with hematologic malignancies (37 male and 18 female). Patients were subdivided into groups: patients with AML, patients with T-ALL, patients with B-ALL, patients with CLL, patients with lymphoma and patients with multiple myeloma. The following investigations were done 1. Full clinical evaluation including Entire history taking including: (age, sex, therapeutic history, blood transfusion).Clinical examination including: (anemic manifestation, fever, hepatomegaly, splenomegaly, lymphadenopathy, bleeding tendency, and bone tenderness) 2- Laboratory investigations include complete blood count: Two ml of venous blood were withdrawn into ethylene diamine tetra acetic acid (EDTA) used immediately for complete blood counting with spreading of peripheral blood smears for Leishman staining and differential leucocytic counting. CBC was done using ADVIA 2120i (Siemens, Germany), including hemoglobin (Hb) level, RBCs indices, total leukocytic count, differential leukocytic count, platelet count, platelet indices, and, reticulocytes. Examination of peripheral blood smears stained with Leishman stain for differential leukocytic count and detection of abnormal cells BMA: sample was collected in EDTA tube for each patient from the anterior or posterior superior iliac spine, half ml of BM aspirate was mixed immediately on glass slides, and smears were spread to be examined after staining by Leishman stain. One ml of BM aspirate was gently dispensed into an EDTA solution tube for Flow cytometry (FCM) immunophenotypic analysis. The sample used for FCM was evaluated.