الفهرس 
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Abstract
Alopecia areata is a safe intervened fiery problem that influences
hair follicles coming about in non-scarring balding. The etiology of AA
isn’t referred to precisely; but factors like hereditary inclination,
autoimmunity, and ecological elements have been proposed.
The TCF7L2 quality, encoding the TCF7L2 protein, is situated on
chromosome 10q25.2-q25.3.
The TCF4 protein assumes a part in the development of cells to do
explicit capabilities (cell separation) and the implosion of cells (apoptosis).
Single-nucleotide polymorphisms (SNPs) rs7903146, inside the
TCF7L2 quality, is, until this point in time, hereditary marker related with
alopecia areata.
Our flow study expected to record factor 7 l2 (TCF4), rs7903146
quality polymorphism in alopecia areata Egyptian patients and regardless
of whether it has a relationship with sickness seriousness.
In the concentrate in our grasp, with respect to the examination
between alopecia patients and controls in regards to mean TCF7L2 (TCF4)
it was found that TCF4 level among patients higher (mean± SD 1.96±0.49)
than control bunch (mean± SD 1.63±0.73) in allel 1and additionally in
allel2 patients bunch higher (mean± SD 2.05±1.47) than control bunch
(mean± SD 1.11±0.89). There was measurably huge contrast between both
gathering in regards to serum level of TCF4 in allel 1 (p= 0.036) and
exceptionally critical in allel 2 (p= 0.006). In correlation between alopecia
patients and control bunch with respect to mean TCF4 polymorphism the T
allel was altogether more in-patient gathering (p= 0.001 _ OR=2.96, 95%
CI=1.49 - 5.88). The consolidating frequencies of TT and genotypes was
essentially higher in those analyzed AA.