الفهرس 
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Abstract
For thousands of years, natural remedies were the only choice for both the treatment and prevention of human ailments. Natural products are crucial sources for the creation of new medications. In natural therapies, the concentrations of bioactive natural compounds are almost never very high. The creation of efficient and focused extraction and separation processes for such bioactive natural compounds is currently of utmost importance. This review aims to present an in-depth analysis of the various techniques employed in the extraction and separation of natural products. This essay also discusses the benefits, drawbacks, and real-world applications of both traditional and contemporary methods used in the study of natural products. The initial stage in separating the desired natural products from the base materials is extraction. According to the extraction principle, there are several extraction procedures, including solvent extraction, distillation, pressing, and sublimation. The technique with the highest usage is solvent extraction. The following steps are taken when natural product extraction advances: The solute diffuses out of the solid matrix after being dissolved in the solvents, which happens in steps one through four. The extracted solutes are then collected. The extraction will be made easier by any element that increases the above steps’ diffusivity and solubility. The extraction efficiency will depend on the qualities of the extraction solvent, the raw material particle size, the solvent to solid ratio, the extraction temperature, and the extraction time.