الفهرس 
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Abstract
Marine organisms remain the most abundant sources of chemical inspiration for therapeutic development. The mostly unexplored marine realm, which is thought to have the largest biodiversity, could be a source of bioactive secondary metabolites with the potential to treat a variety of ailments. On the other hand, disease disorders are modifying patterns, and new diseases are arising as a result of changing environments so it’s important to constantly look out for different sources to develop effective and safe drugs. The genus Hemimycale marine sponge is characterized by its bioactive metabolites, particularly guanidine alkaloids with antitumor, antiviral, antifungal, and anticonvulsant properties. In view of this fact, the crude methanolic extract of the marine sponge Hemimycale sp. was examined for biological active compounds. Different classes of compounds were isolated like as, hydrocarbons, fatty acids, phenolic, sterols, terpenes, ceramide and nitrogenous compounds. Moreover, certain biological activities of the total extract, fractions and some of the isolated compounds were evaluated with the aim to develop a novel remedy for various ailments. The current study of the marine sponge Hemimycale sp. included:
Part I:
Phytochemical study of Hemimycale sp. including:
Extraction, fractionation, isolation, and identification of the main secondary metabolites from the marine sponge Hemimycale sp.
Part II:
Biological studies of Hemimycal sp. including:
Evaluation of cytotoxic activity of the sponge Hemimycale sp. supported molecular docking simulations.
Evaluation of anti-microbial activity of total extract and different fractions of the sponge Hemimycale sp.
Evaluation of anti-leishmanial activity of the isolated compounds from the sponge
Hemimycale sp.