الفهرس 
Hepatocellular CarcinomaOnly 14 pages are availabe for public view
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Abstract
Hepatocellular carcinoma (HCC) is a multifactorial disease with both genetic and environmental factors contributing to its pathogenesis. ACYP2 is a gene that is related to cell differentiation and apoptosis and prevention of malignant tumors. ACYP2 gene also affects telomere length. The aim of this study was to evaluate the association between ACYP2 SNPs (rs843711), and (rs843706) single nucleotide polymorphisms and incidence of HCC in Egyptians. The study included 30 patients who had HCC and 30 healthy controls. Detection of ACYP2 gene SNPs (rs843711), and (rs843706) to all participants was done using real time PCR. Results of the study showed that all participants of the study including HCC patients and healthy controls carried the heterozygous CA (100%) of the rs843706 SNP (p > 0.05). As for rs843711, in HCC patients, (3.3%) had the homozygous TT genotype, (46.7%) had the heterozygous CT genotype and (50%) had the wild CC genotype, while in healthy control group, (60%) had the heterozygous CT genotype and (40%) had the wild CC genotype with no significant difference between both groups (p > 0.05). To conclude, this study did not show an association between in ACYP2 rs843706 and rs843711 and occurrence of HCC.