الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 91 |  |  |
| | | from | 91 | | |
Abstract
Type 1 diabetes is one of the most common chronic diseases in childhood and its symptoms appear as a result of high blood glucose, which may be severe and severe to the point of threatening the life of the child.
Many of the complications of diabetes include retinopathy, which is one of the most serious complications that threaten vision loss.
Ocular computed tomography angiography is one of the latest and most accurate techniques that can accurately determine the blood supply to the eye before symptoms of retinopathy appear.
The vascular endothelial growth factor is one of the most important recently discovered factors that contribute to the generation of blood vessels in many diseases, including diabetes mellitus and its complications.
Aim of the study:
This thesis aims to investigate the possibility of predicting the occurrence of early retinopathy in children with type 1 diabetes by using ophthalmic computed tomography angiography and vascular endothelial growth factor.
Patients and methods:
The study included 50 children with type 1 diabetes attending the diabetes clinic at Minia University Hospital as a first group, and 20 apparently healthy children of similar age for comparison.
The selection criteria were as follows:
1- Their ages range from 5 to 18 years.
2- People with type 1 diabetes for more than 3 years.
3- Normal kidney function.
4- Examination of a normal eye fundus.
The following are excluded:
1- Those under the age of 5 and those over the age of 18.
2- Patients with retinopathy or those with abnormal fundus examination.
3- Abnormal kidney functions.
4- patients with any eye disease, such as glucoma or cataract.
5- children with any chronic diseases.
6- Those on chronic treatment other than insulin.
All groups studied were subjected to the following:
Take a detailed medical history.
A complete clinical examination.
Performing medical analyzes and laboratory tests, which included:
1- Glycosylated hemoglobin.
2- Lipid profile: serum cholesterol, triglycerides, high-density lipoprotein, and low-density lipoprotein.
3- Serum Endothelial growth factor level.
Eye examination using:
1- Fundus Eeamination.
2- Ocular Computed tomography angiography.
The obtained results were analyzed and the following were found:
There is a difference in blood flow through the microvessels of the eye between the two groups, with a higher level of HBA1c, vascular endothelial growth factor, and higher cholesterol, triglycerides, and low-density lipoprotein in the diabetic group than in the apparently healthy group.