الفهرس 
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Abstract
Dina Samir El-said Said Ahmed. Assess the potential role of some gene expression levels (VEGFA, TGFß1, and CD63), expression of IL37, CD64, and CD16A gene polymorphism in diagnosis, etiology, prognosis, and response to treatment in adult Egyptian patients with primary Immune Thrombocytopenic Purpura. Biochemistry Department, Faculty of Science, Ain Shams University.
Background: Immune thrombocytopenic purpura (ITP) is an acquired autoimmune hematologic disorder.
Subjects and Methods: This retrospective case-control study was conducted on sixty patients with primary ITP, sixty patients with other causes of thrombocytopenia, and sixty controls. All ITP patients received corticosteroids. They followed up for one year.
Results: Increased IL-37 level and down regulation of VEGFA and TGFß1gene expression were detected in primary ITP patients when compared with other groups. Interleukin-37 & CD64 were significantly lower in ITP patients with complete remission when compared with others. FcγRIIIA 158 V/F (rs1801274) gene polymorphism in all subjects was wild FF genotype.
Conclusions: Current results suggested that IL-37, VEGFA, and TGF-β1 may be promising indicators in the diagnosis of ITP and detection of disease severity. FcγRIIIa 158 V/F (rs1801274) gene polymorphism does not have a role in ITP patients.