الفهرس | Only 14 pages are availabe for public view |
Abstract Objective: To evaluate the effect of non-surgical periodontal intervention on pregnancy outcome in mild pre-eclamptic women Material and Methods: A total of 50 pregnant women with mild preeclampsia (blood pressure levels ≥140/90 mm and proteinuria >300 mg/l in 24 hours urine) was included to the study and chronic moderate periodontitis. Pregnant women were randomized in two groups, the treatment group (group 1=25) and the control group (group2 =25). All women received oral hygiene instruction. The women in the treatment group received non surgical periodontal therapy during the gestational period and those in control group received periodontal treatment after delivery. Maternal demographic, medical and periodontal data were obtained from both group. Periodontal evaluation was performed and blinded to periodontal treatment, according to plaque index (PI), bleeding on probing (BOP), probing depth (PD), clinical attachment level (CAL), periodontal epithelial surface area (PESA), and periodontal inflamed surface area (PISA) were recorded at baseline (at 20 weeks) and 36 gestational weeks. In addition, samples of blood and GCF were collected. The progression from mild to severe preeclampsia, eclampsia, were evaluated in both groups Results: The periodontal therapy resulted in improvement the periodontal clinical parameters (plaque index, bleeding on probing, periodontal pocket depth and clinical attachment level,) and reduced biomarker levels from gingival crevicular fluid (GCF), and from blood serum. Results indicated a statistically significant reduction in all clinical variables (P = 0.001) and decreased levels of TNF- α (P = 0.001) and IL-6 (P = 0.001) in GCF during the study period. |