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Abstract Background: The key to quality and excellence in Covid-19 patient care is nurses’ adherence to infection control procedures; infection control remains one of the most cost-effective nursing practices and calls for the full cooperation of the entire nursing staff. Aim of the current study is to assess Nursing Staff Compliance regarding Infection Control measures with COVID-19 Patients at Isolation Hospitals. Design: Comparative cross sectional study design was utilized to fulfill the aim of this study. Setting The study was conducted in two of corona virus’s isolation hospitals (Minia Chest Hospital & Minia Fever Hospital) at Minia City, Minia governorate, Egypt. Subjects: The study sample involved (233) of nursing staff working in the prementioned hospitals, who were on duty during the period of data collection. Data Collection Tool: Observational Checklist of Nursing Staff Compliance with Infection Control and Prevention consisting of two parts; personal data sheet followed by Observation Checklist items. Results: Most of the studied nursing staff at the two hospitals had high level of compliance with infection control measures (87.6%), while (12.4%) of them had low compliance level. Also, most of the studied nursing staff at Minia fever hospital had high compliance with protective measures, and linen management (96.6%, 95.8%, respectively), while most of the studied nursing staff at Minia chest hospital had high compliance with safe injection practices, and specimen handling (97.4%, 94.7%, respectively) with statistically significance. Conclusion: The mean scores of total compliance level as well as the mean scores of personal protective equipment and safe injection practices sub-domains were observed higher in the morning shift than in the other work shifts with high statistically significant differences. Recommendations: Ongoing education as well as training for all health care sectors about all waves of the Covid -19 virus. Frequently supervision by management levels to ensure nursing staff compliance with infection control measures during all work shifts. |