الفهرس 
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Abstract
Human papillomavirus (HPV) is the causative agent of the common warts seen most often on children and young people.
Retinoids, cryosurgery, chemical or electric cauterization, and laser based therapy are all viable methods for treating plane warts. Unfortunately, there is currently no foolproof method for eradicating aeroplane warts.
Immunotherapy is an up-and-coming therapeutic option. This necessitates the use of immunomodulators, which boost or stimulate the patient’s immune system.
Immunotherapy is preferable to conventional treatments because it encourages the immune system to recognise the virus, which triggers a delayed - type response that ultimately leads to the removal of the treated warts and, often, warts in unrelated anatomic regions. As a result, the likelihood of a recurrence is reduced, and the treatment is successful in the long run as well, since it confers immunity to the wart antigen. Warts, on the other hand, disappear without leaving any scars.
Studying the efficacy and safety of local anesthetics PPD, TCA 50%, and needling in the treating of plane warts was the focus of this study.
For this study, we analysed data from 53 individuals who sought treatment at the Minia University Hospital outpatient clinic for plane warts. There were four distinct sets of them.
In group I, we have the patients who have been treated with needling, PPD, and TCA.
Needling and PPD were used on patients in group II.
Patients in group III were treated with needling and TCA.
In the fourth group, patients are kept under control by the use of needles.
There was no statistically significant difference between the four groups with respect to age, sex of patients, location, or duration of warts, as measured by a chi-square test (p>0.05).
Ninety-three percent of patients in the needling, PPD, and TCA group had a remarkable response, whereas one patient (6.25 percent) showed a poor reaction towards the end of treatment. Wart counts decreased by an average of 98.974.12%. Eight people (50%) had their lesions cleared up in a single or double treatment session.
At the end of treatments, all patients in the badgering and PPD group reported improvement. Average decline percentage was 100.0 0.0. Seven people (46.7% success rate) had complete lesion clearance after just one or two treatments.
At the end of treatment, all patients in the probing and TCA group reported improvement. Average decline percentage was 100.0 0.0. Ten people (62.5%) were able to get rid of their lesions with just one or two treatments.
Only two patients (33.3%) in the needling group had no response, whereas four patients (66.7%) had a flare of lesions. There was an average decline of 29.8033.63 percentage points. While we initially planned to treat a certain number of patients in this group, we abandoned those plans out of concern for our patients’ welfare and because we saw that haranguing alone either exacerbated the lesions or failed to exhibit response.
Statistically, there was no difference in response grade, number of wart reduction, or quantity of sessions between Groups I, II, and III when compared to group IV (p>0.05), however there was a statistically significant difference between group IV and group II and group III (p0.05).
There was no statistically significant difference in adverse events or therapy-related problems among the four groups examined (p>0.05). 54.7 percent of patients had erythema, 47.1 percent experienced oedema, 49.05% experienced pain, and 32.07% had hyperpigmentaion, all of which resolve on their own time.
Three months after treatment ended, there was no statistically significant difference in recurrence of lesions across groups, according to our evaluation of the patients. When the response was negative at the end of sessions, just one case (6.25%) was recorded as returning. In this particular case, it has been pointed out, a severe depression may have had a role in the development of resistance and subsequent relapses.
Conclusion
Our findings suggest that needling is not an effective treatment for plane warts on its own. There was a dynamic relationship with a quicker acceptable response, little self-limiting side effects, and no recurrence after 3 months of follow-up when TCA, PPD, or both were used together. Use of either TCA or PPD was not noticeably different from their combination use from the perspectives of cost and availability. Our research has shown that combining TCA with needling is an effective alternative regimen for treating plane warts. To the best of our knowledge, this treatment plan is risk-free, easily accessible, and productive. However, the positive effects of PPD on distant warts make its combination use with needling effective in cases when the warts are extensive. However, we recommend further study comparing the effects of TCA alone with those of combining TCA and needling, as well as comparing the effects of PPD alone with those of mixture PPD and needling, to verify the use of addition.