الفهرس 
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Abstract
Alzheimer’s disease (AD) is one of the common causes of dementia. With antioxidant, anti-inflammatory, and cognitive qualities, quercetin has long been recognized as an intriguing medicinal herb. Determining the potential therapeutic and preventive effects of quercetin against Aluminum Chloride (ALCL3)-induced AD was the goal of this investigation.AD was induced by intra peritoneal orally of ALCL3 at a dose (100 mg/kg body weight.) for 60 days. sixty male rats were equally divided into 6 groups. group I (Normal control): Rats received no drugs, group II (ALCL3- induced AD): Rats orally with ALCL3 (100mg/kg body weight ) for 60 days, group III (Quercetin treated): Rats treated with Quercetin (100 mg/kg body weight day) for 60 days, then Rats orally with ALCL3 as group II. group IV (AD + Quercetin treated): Rats orally with ALCL3 as group II and treated with Quercetin (100 mg/kg body weight day, orally) for 60 days. group V (AD+ Donepezil treated): Rats orally with ALCL3 as group II and treated with Donepezil (2 mg/kg body weight day, orally) for 60 days. group VI (AD + Quercetin and Donepezil treated): Rats orally with ALCL3 and treated daily with Quercetin and Donepezil for 60 days.The results found that blood ALT and AST activity, urea, creatinine, and oxidative stress biomarkers were markedly elevated in ALCL3-induced AD mice as well as the brain tissues’ levels of Amyloid beta, tau protein, and acetylcholine. Additionally, ALCL3 altered the expression of certain genes linked to the AD signaling pathways PI3K/AKT/mTOR, Tyk2/STAT3, and GSK-3, as determined by the Western blotting method.Rats with AD received either a pre-treatment or a therapy that significantly improved all previous metrics. In conclusion, the injection of quercetin reduces the oxidative stress, increased levels of amyloid- and tau protein, and disrupted signaling pathways brought on by ALCL3 in the rat AD model. Free radical scavenging activity, strong antioxidant activity, and an anti-cognitive effect of its constituents are credited with these effects (flavonoids, Salvianolic acid and rosmarinic acid).Key words: Alzheimer’s, Quercetin, ALCL3, Amyloid-β, Tau protein, ACH, PI3K/AKT/mTOR, Tyk2 / STAT3, GSK-3β pathways.