الفهرس 
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Abstract
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SUMMARY & CONCLUSION
It has long been observed that about 40% of overweight children will
continue to have increased weight during adolescence and 75−80% of obese
adolescents will become obese adults. A child with a high BMI has a high risk
of being overweight or obese at 35 years of life and this risk increases with age.
The consequences of this disease starting in childhood may be more
severe as the duration of obesity will be longer. It may therefore have a greater
deleterious impact on health and the rate of morbidity and mortality, than
obesity starting in adulthood.
Obesity results in several alterations that have been linked as
co−morbidities of the disease. Hyperinsulinemia is prevalent in obesity and is
strongly linked with cardiovascular disease, type 2 diabetes mellitus,
hyperlipidemia, and hypertension. With few exceptions, the clinical features of
cardiovascular heart disease are not apparent until the third or fourth decade of
life.
Therapeutic strategies to inhibit pigment epithelium derived factor action
in muscle and liver, or prevent adipocyte PEDF release, may prove a viable
approach to ameliorate obesity-induced insulin resistance and its associated
pathologies