الفهرس 
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Abstract
SARS-CoV-2, the causative agent of the global pandemic that resulted in a massive loss of human life, causes coronavirus disease 19 (COVID-19), a highly contagious and dangerous viral illness. Human-to-human transmission occurs quickly, but its intermediate source and mode of transmission remain unknown.
Endothelial activation supports the idea of a COVID-19-associated microvascular dysfunction, and a recent publication suggested that Ang2 in COVID-19 patients was a meaningful predictor to predict transfer to the ICU because of its relationship to poor lung compliance.
This research was conducted between January 2022 and June 2022 at the chest intensive care unit (ICU) and the Clinical Pathology Department at Minia University in Minia, Egypt. The purpose of our research was to examine the effects of angiopoietin2 in people with COVID 19. They tested it on 54 people.
The results of this study were summarized as follow:
• There was no statistically significant difference regarding age when comparing all patients and control groups while it was significant difference when comparing ICU patients and control, also when comparing ICU and non-ICU patients.
• There was no statistically significant difference when comparing sex between all patients and control group, also when comparing ICU patients and control ,also when comparing between ICU and non ICU patients .
• There was statistically significant difference when comparing diabetes mellitus between all patients and control group , also when comparing ICU patients and control ,also when comparing between ICU and non ICU patients .
• There was statistically significant difference when comparing hypertension between all patients and control group , also when comparing ICU patients and control ,but there was no significance difference when comparing between ICU and non ICU patients .
• There was statistically significant difference when comparing fever, cough , dyspnea , sore throat between all patients and control group , also when comparing ICU patients and control ,but there was no significance difference when comparing them between ICU and non ICU patients .
• There was no statistically significant difference regarding loss of taste and smell and GIT manifestations when comparing between all patients and control group , also when comparing ICU patients and control ,also when comparing between ICU and non ICU patients
• There was statistically significant difference when comparing oxygen saturation between all patients and control group , also when comparing ICU patients and control ,but there was no significance difference when comparing it between ICU and non ICU patients .
• There was statistically significant difference regarding urea and creatinine when comparing between all patients and control group, also when comparing ICU patients and control, also when comparing between ICU and non-ICU patients.
• There was statistically significant difference regarding ALT, AST and LDH when comparing between all patients and control group, also when comparing ICU patients and control, also when comparing between ICU and non-ICU patients.
• There was statistically significant difference regarding CRP and serum ferritin when comparing between all patients and control group, also when comparing ICU patients and control, but there was no significance difference when comparing between ICU and non-ICU patients.
• There was statistically significant difference regarding hemoglobin when comparing between all patients and control group, also when comparing ICU patients and control, but there was no significance difference when comparing between ICU and non-ICU patients.
• There was statistically significant difference regarding TLC and absolute neutrophilic count when comparing between all patients and control group, also when comparing ICU patients and control, but there was no significance difference when comparing between ICU and non-ICU patients.
• There was statistically significant difference regarding absolute lymphocytic count when comparing between all patients and control group, also when comparing ICU patients and control, also when comparing between ICU and non-ICU patients.
• There was no statistically significant difference regarding platelets when comparing all patients and control groups also when comparing ICU and non-ICU patients while it was significant difference when comparing ICU patients and control.
• There was statistically significant difference regarding PC and INR when comparing between all patients and control group, also when comparing ICU patients and control, but there was no significance difference when comparing between ICU and non-ICU patients.
• There was statistically significant difference regarding APTT when comparing between all patients and control group, also when comparing ICU patients and control, but there was no significance difference when comparing between ICU and non-ICU patients.
• There was statistically significant difference regarding D-Dimer when comparing between all patients and control group, also when comparing ICU patients and control, but there was no significance difference when comparing between ICU and non-ICU patients.
• There was statistically significant difference when comparing angiopoietin 2 between all patients and control group, also when comparing ICU patients and control, also when comparing between ICU and non ICU patients.
• In patients with COVID 19, there was a statistically significant positive relationship between oxygen saturation and PC.
• In addition, LDH and CRP showed a strong positive connection in a sample of 19 individuals with COVID.
• In addition, LDH and s.ferritin showed a strong positive connection in a sample of 19 individuals with COVID.
• LDH and D.dimer had a strong positive connection in this group of COVID 19 patients as well.
• C-reactive protein and D-dimer levels were positively correlated in COVID 19 individuals.
• In addition, s.ferritin and APTT were significantly negatively correlated in 19 individuals with COVID.
• Absolute lymphocyte counts and PC were positively correlated in COVID 19 individuals as well.
• Absolute lymphocyte count and angiopoietin 2 showed a strong inverse relationship in COVID 19 participants.
• Among addition, in COVID 19 patients, there was a very significant inverse relationship between PC and INR.
• In addition, there was a negative connection between PC and APTT in 19 individuals with COVID.
• For COVID 19 individuals, there was a favourable association between INR and APTT as well.