الفهرس 
AbstractOnly 14 pages are availabe for public view
 |  | from | 91 |  |  |
| | | from | 91 | | |
Abstract
Summary
NAFLD is currently considered the most common chronic liver disease worldwide. NAFLD is considered a hepatic manifestation of metabolic syndrome, and is therefore associated with various disorders, such as renal dysfunction, cardiovascular disease, and sexual dysfunction Alteration of sexual function,inparticular,erectiledysfunction(ED),whichisdefinedastheinability to achieve or maintain an erection sufficient for satisfactory sexual performance, isthoughttobequitecommonamongthosewithadvancedliverdisease.
The aim of this study is to assess the serum level of adropin as amarker in men with NAFLD associated ED compared to NAFLD patients with normal erectile function (EF) and healthy controls.
This is a cross sectional study that was carried out on 90 patients who visited Department of Andrology at Beni-Suef University Hospital, from November, 2021 to March, 2023. All patients underwent clinical examination and investigations for assessment according to theircondation.
This study encompassed 90 participants divided into the following groups as following:
• group I: 41 patients with NAFLD who reported an IIEF-5 score ≤21.
• group II: 30 patients with NAFLD who reported an IIEF-5 score >21.
• group III: 19 healthy control subjects who showed normal EF according to IIEF-5scores.
Initially all participants were checked for their erectile function using a single item questionnaire, Erection Hardness Score (EHS) (Mulhall et al., 2007), but final classification of study groups was based on the reliable 5 item version of IIEF (IIEF-5).
All participants underwent full personal, sexual, and medical history taking, and assessed via using the following questionnaire Erection hardness score (EHS), (International Index of Erectile Function (IIEF-5), Patient Health Questionnaire-9 (PHQ-9), and 7-item Generalized Anxiety Disorder Scale (GAD-7)). In addition, height, weight, vital signs, and signs of hypogonadism, body mass index (BMI), waist circumference were registered. Finally, laboratory data (serum adropin, glucose, aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine, albumin, bilirubin , fasting lipidprofile , hemoglobin (Hb), INR, fasting blood sugar (FBs) and HbA1c levels, were assessed.
In the present study, waist circomference, (PHQ9), and (GAD7) were significantly higher in NAFLD patients with or without ED than in control group. Moreover, (IIEF-5) score and (EHS) were significantly lower in NAFLD with ED than both NAFLD without ED and control groups.
In addition, fasting blood sugar (FBS) and HbA1c was significantly higher in NAFLD with ED than in NAFLD without ED group and controlgroup.
Further more , there was significant positive correlation between IIEF-5 score and serum adropin, and TT. However, the correlation between IIEF-5 score and (PHQ9 score and GAD7, Hb, creatinine) was significantly negative.
There were significant positive correlations between EHS and serum adropin. However, the correlation between EHS and (PHQ9 score, creatinine and GAD7 score,) was significantly negative.