الفهرس 
OPIOID FREE ANESTHESIA AND ERASOnly 14 pages are availabe for public view
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Abstract
Patients and Methods: This interventional, randomized and double–blinded controlled trial study was conducted in the institute Hospitals, Ain Shams University Hospitals from 1 February, 2023 to 31 July, 2023. The purpose of the study was clarified to all patients in full detail, along with details of the anaesthesia technique to be used by both the surgeon and anaesthetist. Moreover, informed consent was signed by all patients who were scheduled for lumbar spine procedures on any levels between L1 and L5. Subjects were eliminated from the study if they refused to participate, were unable to evaluate their level of pain or had an allergy to the study drugs.
Results: Our results indicate that there were no significant differences in SBP and episodes of hypertension between the two groups during various stages of the surgical procedure. However, HR values showed less fluctuations in OFA group starting from after skin incision and throughout different stages of the surgery. Our population who are at high risk of postoperative nausea and vomiting due to previous opioid use on chronic back pain. In our study, incidence of PONV in group OFA was lower than that of in group OA in a period of 24h after surgery (5.7%, 15.7%).
Conclusion: Compared to OA technique, OFA technique, which is represented by non-opioid drugs, lidocaine and dexmedetomidine, may be an alternative anesthesia in patients undergoing posterior lumbar spine fusion surgery. With its non-inferiority of analgesic effect, safe anesthesia, and lower incidence of intraoperative hemodynamics fluctuations and PONV.