الفهرس | Only 14 pages are availabe for public view |
Abstract In hospitalized patients especially those admitted to the ICU, the gut provides a reservoir for MDROs (Multidrug resistant Organisms) and those with MDRO colonization are at risk of contracting many complications and HealthCare Associated Infections (HCAIs) spreading them to others. To decrease MDRO carriage, infection prevention methods should focus on the gut microbiome. Recent clinical studies indicated approaches to control the microbiota in the ICU to treat or prevent infections. Repletion of health-promoting bacteria via probiotics has been hypothesized to be promising intervention to maintain gut integrity and to prevent loss of intestinal epithelial barrier function, which is associated with systemic inflammatory response syndrome sepsis. Thus, analyzing the pattern of gut microbiome at admission, can be used to prevent the development of HAIs or even reducing it through it’s use as a predictor for HAIs and all of these for further manipulation. |