الفهرس 
UTERINE LEIOMYOMAOnly 14 pages are availabe for public view
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Abstract
Background: Symptomatic Uterine leiomyomata may lead to many symptoms including abnormal uterine bleeding, mass pressure effects and infertility. Myomectomy is an option for conservative management, however, it is associated with some disadvantages, mainly increased intra-operative blood loss. Intra-myometrial vasopressin injection during myomectomy is an effective method to decrease the intraoperative bleeding due to its vasoconstrictor effect. Octreotide Acetate (OA) is another vasoconstrictor agent that have not been tested for gynecologic indications.
Objective: To test the efficacy of the local vasoconstrictive effect of OA in reducing blood loss during trans-abdominal myomectomy, and to compare it to the local vasoconstrictive effect of vasopressin.
Patients and Methods: This prospective double-blind randomized controlled trial was conducted at Ain Shams University Maternity Hospital to test the efficacy of the local vasoconstrictive effect of OA in reducing blood loss during trans-abdominal myomectomy, and to compare it to the local vasoconstrictive effect of vasopressin. 40 women were randomized into 2 equal groups; group (A): where local vasopressin was used and group (B): where OA was used.
Results: Regarding operative time; statistical analysis of current results showed that there was significant positive correlation between it and blood loss, change and percent of change in hemoglobin while, there was no significant correlation between it and postoperative hemoglobin, postoperative change and percent of change in HCT. Regarding postoperative complications “bradycardia and ICU admission”; statistical analysis of current results showed that they were non-significantly more frequent in local vasopressin group
Conclusion: In cases of trans-abdominal myomectomy, octeteotide acetate is a good option to be used in reducing blood loss but it’s not as potent as vasopressin with more operative time but with the same need for blood transfusion and safer with less side effects and cheaper in comparison to vasopressin.