الفهرس 
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Abstract
Acute ischemic stroke (AIS) is one of the major causes of death worldwide. Currently, intervention can dramatically improve outcome and reduce disability. Acute ischemic stroke causes a great financial burden, since one-third of surviving stroke patients remain dependent in daily activities (Zi & Shuai, 2014). Studies have been conducted to find out the factors which can help in formulating the prognosis of acute ischemic stroke. Prognostic indicators, which has gained great clinical interest in recent times, are serum ferritin and D-dimer (Garg et al., 2020). Thus, the aim of the current study is to assess the correlation between serum levels of both ferritin and D-dimer and severity of acute ischemic stroke at time of presentation and its relationship with the short-term outcome of patients. The present study is an observational prospective study with analytic component that was carried out on 100 patients attending neurology department at Mansoura university, the mean age of the studied cases is 65.66 years ranging from 35 to 94 years, 54% are females, 52% not working, 64% from urban areas, 80% married, presenting with acute ischemic stroke. To the best of our knowledge, there were limited numbers of studies that discussed the role of ferritin in the context of stroke. The majority of previous researches were mainly emphasized on D-dimer only. The current study demonstrates that 48% and 34% of the studied cases are associated with significant increases in both D-dimer and ferritin respectively. This come in the same line with several studies which have demonstrated that; D-dimer concentrations were significantly higher in acute stroke patients compared to healthy controls (Abbas et al., 2021; Garg et al., 2020; Yuan et al., 2021; Zi & Shuai, 2014). With regard stroke scale, the current study demonstrates that; there is a statistically significant positive correlation between D-dimer and NIHSS initial and between D-dimer & NIHSS at short term follow up. It demonstrates that presence of cardiac disease, thrombolytic therapy administration, NIHSS initial are statistically significant predictors of D-dimer among studied cases with 54.5% of D-dimer is predicted by changes in previous factors. D-dimer derived from the cross-linked fibrin network is a final soluble fibrin degradation product which undergoes plasmin-mediated degradation (Weitz et al., 2017). There are several possible explanations for why plasma D-dimer levels might be relevant to poor functional outcome in patients with AIS. For instance, plasma D-dimer level increases in blood coagulation and degradation of fibrin and could be a marker of thrombosis based on the underlying mechanisms (Kogan et al., 2016; Matsuo et al., 2000). Similarly, Abbas and his colleagues have demonstrated that; there was a statistically significant correlation between D-dimer at admission and D-dimer after 24 hours and NIHSS (Abbas et al., 2021). Also, Ramos-Pachón and his colleagues have selected (NIHSS≥10) as the best cutoff point in prediction of large vessel with significant increases in both D-dimer and ferritin respectively.