الفهرس 
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Abstract
ABSTRACT
The current study aimed to investigate the ameliorative or protective effect of Zinc oxide resveratrol nanoparticles (RSVnps) against testicular and hepato-renal toxicity induced by Levofloxacin (LFX). Fifty male rats were randomly allocated into 5 groups (n=10). G1 (control group): orally gavaged distilled water; G2: orally gavaged LFX (40 mg. Kg-1 B.W) every other day for 8 weeks; G3: orally gavaged RSVnps (20 mg kg-1 B.w) every other day for 8 weeks; G 4: was co-treated with RSVnp (as in G3) along with LFX (as in G2) for 8 weeks; G5: was co- treated with LFX (as in G2) and Zno nps (20 mg kg-1B.W) for 8 weeks. LFX increased serum level of alanine aminotransferase, aspartateamino transferase, urea, creatinine, it caused no change in serum level of total protein, albumin. However, It decreased nitric oxide, catalase, and superoxide dismutase levels. The results were parallel to histopathological findings which revealed hemorrhage, congestion, severe degeneration and edema of the testicular tissues. In regard to the liver, there were sporadic cell necrosis in hepatocytes, central vein and blood sinusoids revealed a dilatation and a congestion in central vein and sinusoids also, there was proliferation of Kuppfer cells. Moreover, the Hemorrhage and hemosiderosis in liver parenchyma and congestion of portal blood vessels. In contrast, RSV reversed the LFX-induced the biochemical and histopathological alterations in liver, kidney and testes functions and and structures. In conclusion, these findings suggest the use of RSV as a potential protective and therapeutic agent for LFX-induced toxicity. This effect of RSVnp is mostly due to its anti-oxidant activities.
Keywords: Resveratrol, Levofloxacin, Zinc oxide, ALT, AST