الفهرس 
ITPOnly 14 pages are availabe for public view
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Abstract
In (ITP) patients there is an autoimmune pathology characterized by a decrease in platelet count, skin discoloration called purpura and hemorrhagic episodes occurs by antiplatelet autoantibodies.
Pulmonary hypertension (PH) is a complex, multisystemic disease defined by a pulmonary arterial pressure higher than 25 mm Hg at rest
(ECD) is a syndrome induced by diverse intrinsic and extrinsic factors which lead to alterations in the barrier function of the vascular endothelium, as well the anti-thrombogenic properties, angiogenic competence and the proliferative capacity are disturbed, dysregulation of vascular smooth muscle tonicity is found too. as well as the migratory properties; and perturbed synthetic functions and impedance of neutrophils and monocytes from diapedesis.
Thrombocytopenia and ECD are known as a cause of spontaneous leakage of blood at the microvascular. a cross-reaction happens between Platelet antibodies and EC antigens and cause extensive endothelial damage, and indeed increase bleeding.
Platelets which contain many pro-inflammatory, angiogenic, and pro-thrombotic mediators which are released upon activation are the second most numerous cells in the blood.
Endothelial lesions are a mark in severe PH, as they significally reduce the luminal area. We documented the presence of concentric lesions in vascular segments proximal to plexiform lesions , occlusion in Pulmonary arteries may also happens by the accumulation of acellular matrix, followed by a terminal scarring process.