الفهرس 
Aim of workOnly 14 pages are availabe for public view
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Abstract
Central corneal thickness (CCT) is an important indicator of corneal health status. It is an essential tool in assessment and management of corneal diseases as it gives an estimate of the corneal barrier and endothelial pump function. Also, CCT is a measure of corneal rigidity and consequently has an impact on the accuracy of IOP measurement by applanation tonometry.
The perimenopausal period is characterized by the loss of sex hormones and is accompanied by a series of changes in the body. Regarding the visual system, changes can occur to the corneal and ocular surfaces.
Studies have reported that E2 changes corneal thickness and that corneal thickness significantly decreases as E2 decreases. However, another one reported that the relationship between E2 deficiency and reduced corneal thickness was non-significant.
Aim of the work:
The aim of the current study was to evaluate the central corneal thickness in premenopausal and postmenopausal women.
Study Design:
This was an observational cross sectional non-interventional study conducted on 60 eyes of premenopausal and postmenopausal women (Age between 50-65 years) at cornea and refractive unit at a private eye center.
The current study revealed the following results:
The age was significantly increased among postmenopausal women compared to premenopausal ones.
Both BCVA and IOP were comparable among both groups with no significant difference.
BCVA and IOP demonstrated insignificant correlation with postmenopausal state.
The average CCT was significantly increased in the pre group compared to the post one.
Both of ECC and CCT could be used as significant predictors of the postmenopausal state.
Conclusion The current study demonstrated that postmenopausal women were associated with an increase in CCT and more Endothelial cell count changes compared to premenopausal ones. However, IOP and BCVA seemed to be comparable with no significant differences.