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Abstract
The aim of this study was to evaluate the effect of smoking and periodontal disease on concentration of total glutathione in saliva and to investigate the effect of mechanical subgingival debridement on salivary glutathione level. The study will include 30 patients retrieved from the outpatient clinic of the department of periodontology, Faculty of oral and dental medicine, Cairo university. The patients will be divided into three groups: group 1: Will include 15 non - smoking patients with generalized moderate to severe chronic periodontitis. group 2: Will include 15 smoking patients with generalized moderate to severe chronic periodontitis. group 3: Will include 10 non - smoker subjects (controls) with clinically healthy periodontium. All the study individuals will be subjected to comprehensive oral diagnosis using the department oral diagnosis charts. The patients will be subjected to the following measurements: plaque index, gingival index, periodontal probing depth, clinical attachment level and full mouth radiographs. At base line, all patients will receive: Oral hygiene instructions and Full mouth supragingival scaling and subgingival clinical debridement in 3 - 4 sessions