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Abstract
Background: The Outcome of patients diagnosed with ST elevation myocardial infarction (STEMI) varies widely despite similar presentation and management., this heighlights the importance of establishing prognostic predictors for those patients. Osteopontin (OPN) expression increases with coronary artery disease(CAD), where it is associated with increased cardiac myocytes apoptosis and myocardial dysfunction, hence it is implicated to be a marker for occurrence of major adverse cardiac events (MACE). Objective: To study the role of serum OPN level as a potential short term prognostic marker for the occurrence of MACE in patients presenting with STEMI and to study the correlation with infarction size (IS) measured by resting myocardial perfusion imaging. Results: Patients with STEMI had higher OPN levels (106 ±15 ng/ml) on admission than the control subjects (27.5 ±12.7ng/ml, P = 0.01). Mean IS was (21.88±8.99). There was a statistically significant relationship between OPN level and LV systolic dysfunction (r: 0.3 ,p: 0.045).Yet , there was no statistically significant correlation between OPN level and mortality or reinfarction (r: 0.2 , p:0.08, r: 0.12 ,p:0.075,respectively).we found a significant statistically significant relationship between IS and LV systolic dysfunction (r0:0.9,p<0.001)and between IS and mortality(r:0.6,p:0.003). OPN level were significantly correlated with the IS. (r:0.3 ,p:0.045)