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Abstract
A voltammetric study of hydrochlorothiazide (HTZ) at activated carbon paste electrode was carried out. The drug in phosphate buffer (0.2 M, pH 7.7) is oxidized at +800 mV using 100 mV s⁻¹ scan rate, giving rise to a well-defined anodic peak. The study indicated that the oxidation process is irreversible and diffusion-controlled. A sensitive, simple and time-saving anodic cyclic voltammetric procedure was developed. The procedure has been applied for the drug determination in pure form and in some commercial tablets with no prior extraction. HTZ showed a significant current response at activated carbon paste electrode under the optimum conditions with two linear dynamic ranges (detection and quantification limits of 2{u00D7}10⁻⁶ M and 6{u00D7}10⁻⁶ M, with linear calibration ranges between 6.5{u00D7}10⁻⁶ - 1{u00D7}10⁻⁴ M and 1{u00D7}10⁻⁴ - 3{u00D7}10⁻³ M HTZ, respectively)