الفهرس 
vitiligo in the periocular skinOnly 14 pages are availabe for public view
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Abstract
Background: Vitiligo is an acquired depigmentary disorder characterized by destruction of melanocytes. The activity of vitiligo influences the clinical outcome and alters the choice of treatment modality. Intestinal fatty acid binding protein (I-FABP), also called FABP2, is solely expressed in intestinal enterocytes of mammals.
Aim of work: The current study aimed to evaluate the levels of serum and tissue I-FABP in patients with vitiligo, verify the relationship between this marker and vitiligo, and compare them with their levels in serum and tissue of age and sex matched healthy control.
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Patients and methods: This study included 44 participants classified into 2 groups, 22 subjects with vitiligo and 22 subjects age and sex matched healthy controls. Skin biopsies from the edge of vitiliginous lesions and serum samples were taken from patients. Skin biopsies and serum samples were taken from controls. Enzyme-linked immunosorbent assay (ELISA) test was used to measure tissue and serum I-FABP.
Results: There was a statistically significant elevation of tissue and serum I-FABP in vitiligo patients compared to controls. Moreover, IFABP level in serum was increased with the sudden onset to Triple the level of that of the gradual onset. There was also statistically significant difference as regards to duration, psychic stress, family history and VIDA and these factors are the predictors of progression of the disease denoting that serum I-FABP may be a marker of activity of vitiligo. Tissue I-FABP was increased with sudden onset than with gradual onset and also with positive family history. Although the level of I-FABP was
increased in psychic stress and VIDA score 3 and 4 but didn’t reach statistical significant value.
Conclusion: This study suggests the possible role of I-FABP in the pathogenesis of vitiligo and links I-FABP to disease activity. Subsequently, I-FABP can be targets for future therapies.
Key words: Vitiligo, activity markers, I-FABP.