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العنوان
Role of Surfactants and Macromolecules in Drug Analysis /
المؤلف
El-Khateeb, Basma Zakaria Mohamed.
هيئة الاعداد
باحث / Basma Zakaria Mohamed El-Khateeb
مشرف / Sherin F. Hammad
مشرف / Samah F. El-Malla
مشرف / لايوجد
الموضوع
Pharmaceutical Analytical Chemistry.
تاريخ النشر
2023.
عدد الصفحات
283 p. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
الصيدلة ، علم السموم والصيدلانيات
تاريخ الإجازة
13/6/2023
مكان الإجازة
جامعة طنطا - كلية الصيدلة - الكيمياء الصيدلية التحليلية
الفهرس
Only 14 pages are availabe for public view

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Abstract

The thesis studied the role of surfactants and macromolecules as organized media to enhance spectroscopic characters of different drugs and the use of this effect to develop new analytical methods for assay of those drugs in pharmaceutical preparation and human plasma. In addition, the thesis introduced the use of surfactants and macromolecules as mobile phase additives in micellar liquid chromatography to improve the chromatographic and/or to enhance the fluorometric detection of poorly fluorescent minor components. The developed methods’ greenness has been evaluated by different tools: Analytical Eco-scale, GAPI and AGREE scale which prove that all developed methods are green as surfactants and macromolecules were used as safer alternatives to organic solvents. The developed methods were successfully applied for the determination of the studied drugs in their lab prepared mixture containing all possible excipients present in their dosage forms or in human plasma.